Dydrogesterone: What It Is, How It Works, and What You Need to Know

When your body doesn’t make enough progesterone, dydrogesterone, a synthetic hormone designed to mimic natural progesterone. Also known as dydrogesterone, it helps regulate the menstrual cycle, support early pregnancy, and treat conditions like endometriosis and recurrent miscarriage. Unlike some other progesterone-like drugs, dydrogesterone doesn’t turn into other hormones in your body—it works exactly where it’s needed, with fewer side effects.

People often confuse dydrogesterone with natural progesterone or other progestins like medroxyprogesterone. But dydrogesterone is different. It doesn’t cause drowsiness the way some progestins do. It doesn’t raise blood pressure like others. And unlike injectable progesterone, you take it as a simple pill. That’s why doctors in Europe and Asia have used it for decades to help women with irregular periods, luteal phase defects, and those trying to conceive. It’s not a fertility drug on its own—but when your body lacks the right hormonal signal to hold onto a pregnancy, dydrogesterone steps in as that signal.

It’s also used for endometriosis and premenstrual syndrome when other treatments fail. Studies show it reduces pain and bleeding better than placebo, with fewer mood swings than some alternatives. If you’ve been told your progesterone levels are low during the second half of your cycle, dydrogesterone might be the missing piece—not because it boosts hormones, but because it replaces what’s missing.

You’ll find posts here about how it compares to other hormonal treatments, what side effects to watch for, and how it interacts with other medications. Some people take it with estrogen for hormone replacement. Others use it alone after IVF. There are stories from women who got pregnant after years of trying, and others who had to switch because of nausea or headaches. You’ll see real experiences—not just textbook definitions.

It’s not for everyone. If you have liver disease, unexplained vaginal bleeding, or a history of certain cancers, your doctor will avoid it. But for many, it’s a quiet, effective tool that doesn’t make you feel like a different person. No weight gain. No brain fog. Just steady support when your body needs it most.

Below, you’ll find real guides from people who’ve used dydrogesterone—what worked, what didn’t, and how they managed the process. Whether you’re just starting out or have been on it for months, there’s something here that matches your situation.